Breast cancer biology 'changing'

The lifestyle changes and the sifting shifted the type of breast cancers that women are diagnosed with above the last couples of the decades, research suggests.

The women are now to have tumours hormone-dependent and on slow growth, a comparison of the fabric samples coming from the Eighties and the exposures of the Nineties.

The researchers Scot also found survival improved with time, the British newspaper of reported Cancer.

More than 40.000 women are diagnosed with breast cancer with RU annually.

The preceding studies suggested that breast cancers can be generally hormone-dependent that in the past.

Specifically it is thought that positive cancers of oestrogen-receiver can be on rise.

These is the tumours which answer the therapy of hormone well, as tamoxifen which prevents the disease returning.

But it was not clearly that the numbers were really on rise as the capacity to detect these types of tumours in the laboratory could be improved these last years.

In the last study, the researchers re-examined the real samples of fabric - 420 of between 1984 and 1986 and 653 of 1996 to 1997 - saved by two large hospitals in Glasgow.

Those diagnosed during all the time of time earlier had presented with symptoms of cancer because the sifting by mammography had not been still presented.

The proportion of cancers which were positive of oestrogen-receiver changed significantly 64.2% to 71.5% during the ten years period.

And more cancers were diagnosed like tumours with rapid growth of the category one - tumours of slow growth, with a decline in the number of the category three -.

There was no change with the time of the proportion of cancers of progesterone or positive Her-2

It could be that the sifting detects more positive cancers of oestrogen-receiver because they are of slow growth and can be detected before the symptoms appear.

But another explanation could be changes of the factors of lifestyle which increase the risk of hormone-dependent tumours, such as women having babies with an old age, with obesity after menopause and the use of the therapy of replacement of hormone.

The researchers, carried out by Dr. Sylvia Brown to the hospital of Crosshouse in Ayrshire wrote: Obviously the percentage of all the children being constant to the old mothers 35 years and more increases in Scotland and this average BMI and the prevalence of obesity increase.

She added that if there is a true increase in the proportion of these tumours she has implications for decisions of treatment that as many clinical tests was carried out in previous decades.

Dr. Alison Ross, research on cancer RU 'elder Officer Information of the science of S, said: Him 's plausible that the lifestyle exchange could influence the types of breast cancers which women develops but will require us of the studies much larger to discover if this tendency is true.

And him 's also not clearly if these results reflect a variation in the biology of breast cancer or indicate that the sifting is better to detect certain cancers.

If the tendency identified in this interesting study is confirmed and continues, it could make apply an impact to the doctors in manner of the results starting from breast cancer studies decades ago made with the treatments in service today.